Cutaneous T-cell lymphoma of the mycosis fungoides type: report of case series

Main Article Content

Yan de Castro Souza
https://orcid.org/0009-0006-1210-2217
Jandir Mendonça Nicacio
https://orcid.org/0000-0001-9139-2414
Fernando Dias Neto
https://orcid.org/0000-0002-6744-8024
Heverton Garcia de Oliveira
https://orcid.org/0000-0001-7698-020X
Dannyel Macedo Ribeiro
https://orcid.org/0000-0001-5922-1260
Tania Rita Moreno de Oliveira Fernandes
https://orcid.org/0000-0002-7061-2825

Abstract

Cutaneous T-cell lymphomas represent a heterogeneous group of lymphoproliferative diseases characterized by skin infiltration by mature malignant T cells. More than 40% of cutaneous T-cell lymphomas are represented by mycosis fungoides. As they present non-specific cutaneous manifestations, they are often underdiagnosed. This article reports four cases of mycosis fungoides with different subtypes treated by a multidisciplinary team, highlighting aspects related to clinical heterogeneity and diagnostic, therapeutic and differential diagnostic challenges, followed by a brief review of the literature. The cases described demonstrate the heterogeneity of cutaneous and systemic clinical signs, with presentations that present a significant diagnostic challenge due to other diseases with similar manifestations, especially for non-specialist physicians in basic healthcare units. Mycosis fungoides continues to be a problematic diagnosis, as the cases described had varied presentations and numerous inconclusive biopsies. Low clinical suspicion and technical limitations in the analysis of biopsies of skin lesions were the main factors implicated. It is hoped that this series of cases will bring a better understanding of the diagnostic aspects of this disease.

Article Details

How to Cite
Souza, Y. de C., Nicacio, J. M., Dias Neto, F., Garcia de Oliveira, H., Ribeiro, D. M., & Fernandes, T. R. M. de O. (2024). Cutaneous T-cell lymphoma of the mycosis fungoides type: report of case series. Brazilian Journal of Case Reports, 5(1), bjcr2. https://doi.org/10.52600/2763-583X.bjcr.2025.5.1.bjcr2
Section
Clinical Case Reports
Author Biographies

Yan de Castro Souza, Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF)

Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina (PE), Brazil.

Jandir Mendonça Nicacio, Hematologist and Professor, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF)

Hematologist and Professor, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina (PE), Brazil.

Postgraduation Program in Human Ecology and Socio-Environmental Management, Bahia State University - UNEB, Juazeiro, Bahia, Brazil.

Division of Hematology/Oncology, Hospital Dom Tomás, Petrolina, Pernambuco, Brazil.

Fernando Dias Neto, Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF)

Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina (PE), Brazil.

Heverton Garcia de Oliveira, Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF)

Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina (PE), Brazil.

Dannyel Macedo Ribeiro, Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF)

Graduating student in Medicine, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina (PE), Brazil.

Tania Rita Moreno de Oliveira Fernandes, Dermatologist and Professor, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF)

Dermatologist and Professor, School of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina (PE), Brazil.

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