Perforating Reactive Collagenosis: A Rare Cutaneous Manifestation of Systemic Diseases

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Published: Jan 18, 2026
DOI: https://doi.org/10.52600/2763-583X.bjcr.2026.6.1.bjcr151
Keywords:
Type II Diabetes Mellitus, Chronic Kidney Disease, Reactive Perforating Collagenosis

Main Article Content

Carolina Cardoso
Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)
https://orcid.org/0000-0002-5954-5385
Pedro Dias dos Santos
Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)
https://orcid.org/0009-0002-7344-5927
David Furtado
Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)
Tiago Alves
Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)
https://orcid.org/0000-0002-3188-0309

Article Details

How to Cite
Cardoso, C., Santos, P. D. dos, Furtado, D., & Alves, T. (2026). Perforating Reactive Collagenosis: A Rare Cutaneous Manifestation of Systemic Diseases. Brazilian Journal of Case Reports, 6(1), bjcr151. https://doi.org/10.52600/2763-583X.bjcr.2026.6.1.bjcr151
Issue
Vol. 6 No. 1 (2026): January/December - 2026
Section
Clinical Images
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Author Biographies

Carolina Cardoso, Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)

Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS), Torres Novas, Portugal.

Pedro Dias dos Santos, Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)

Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS), Torres Novas, Portugal.

David Furtado, Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)

Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS), Torres Novas, Portugal.

Tiago Alves, Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS)

Local Health Unit of Médio Tejo (ULS Médio Tejo), National Health Service (SNS), Torres Novas, Portugal.

References

Herzinger T, Schirren CG, Sander CA, Jansen T, Kind P. Reactive perforating collagenosis – transepidermal elimination of type 4 collagen. Clin Exp Dermatol. 1996;21:279–282.

Hoque SR, Ameen M, Holden CA. Acquired reactive perforating collagenosis: four patients with a giant variant treated with allopurinol. Br J Dermatol. 2006;154:759–762.

Zhang L-W, Wu J, Xu R-H, Chen T. Acquired reactive perforating collagenosis in a patient with diabetes. Cleveland Clinic Journal of Medicine. 2024;91(4):213-214.