Chondroblastic osteosarcoma in a feline: a case report
Main Article Content
Abstract
Osteosarcomas are noteworthy as one of the main malignant bone tumors in dogs and cats, comprising an important cause of limb amputation in these species. Literature reports for felines are, however, scarce. Therefore, the aim of the present study was to characterize the clinical and histopathological findings of a chondroblastic osteosarcoma case in a female cat. The chondroblastic osteosarcoma diagnosis was based on radiographic, cytological, histopathological and immune-histochemical findings. Clinical, radiographic, and cytological findings suggested a presumptive osteosarcoma diagnosis, while histopathological and immune-histochemical findings confirmed a chondroblastic osteosarcoma diagnosis.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Souza LA, Dias TA, Helou JB, Dias BS, Fares NB, Mota FCD, Almeida EM, Pereira LA, Silva TP. Condrossarcoma na articulação femoro-tíbio-patelar de um cão: relato de caso. PubVet. 2014 Jun;8(12):1416-1550.
Aulakh KS, Kielb JL, Hsiao SH, Barnes K, Aulakh HK. Malignant Soft Tissue Sarcoma at the Site of Corticosteroid Injection in a Dog. J vet Sci Anim Husb. 2018 Feb28;6(1):2348-9790, 2018. doi:10.15744/2348-9790.6.102.
Brodey RS, Riser WH. Canine osteosarcoma: A clinico‐pathologic study of 194 cases. Clin Orthop Relat Res. 1969 Jan-Feb;62:54-64.
Jacobsen SA. The Comparative Pathology of the Tumors of Bone. Springfield, IL.: Bibliography, p. 423-446, 1971.
Esmaili Nejad MR, Vafaei R, Masoudifard M, Nassiri SM, Salimi A. Aggressive chondroblastic osteosarcoma in a dog: A case report. Vet Res Forum. 2019 Dec15;10(4):361-364. doi: 10.30466/vrf.2019.100779.2402.
Wegge B, Deneut K, Gasthuys F, Chiers K, Ducatelle R. Chondroblastic osteosarcoma of the humerus in a horse. J Comp Pathol. 2012;146(1):78. doi: 10.1016/j.jcpa.2011.11.134
Peixoto TDC, Silva DN, Araújo BR, Farias SS, Pinto MPR, Requião LGT, Muramoto C, Madureira KM. Osteossarcoma condroblástico mandibular em relato de caso bovino. Braz J Vet Med. 2016;38(Supl. 1):60-64.
Luca Bossa LM, Mennonna G, Meomartino L, Paciello O, Ciccarelli F, Biase D, Raia P, Caputo V, Fioretti A, Dipineto L. Polyostotic Chondroblastic Osteosarcoma in a Kestrel (Falco tinnunculus). J Avian Med Surg. 2015 Dec;29(4):336-339. doi: 10.1647/2014-052.
Moreira LGA, Carvalho TP, Oliveira AR, Santos DO, Paula NF, Tinoco HP, Coelho CM, Santos RL. Metastatic osteoblastic osteosarcoma in a captive scarlet macaw (Ara macao). Braz J Vet Pathol. 2020;13(3):602–608. doi: 10.24070/bjvp.1983-0246.v13i3p602-608.
Needle D, Mcknight CA, Kiupel M. Chondroblastic Osteosarcoma in Two Related Spiny-Tailed Monitor Lizards (Varanus acanthurus). J Exot Pet Med. 2013 jul;22(3):265–269. doi: 10.1053/j.jepm.2013.08.013.
Thompson KG, Dittmer KE. Tumors of Bone. In: Tumors in Domestic Animals. John Wiley & Sons, 2017. pp. 356-424.
Tolosa EMC, Rodrigues CJ, Behmer AO, Neto AGF. Manual de técnicas para histologia normal e patológica. 2nd ed. Barueri, SP: Manole; 2003, 331p.
Gârjoabă I, Tudor N, Soare T, Tănase A, Alistar A, Vlăgioiu C. A study on the prevalence of skeletal osteosarcoma in dogs and cats. Lucr Stiinţ Ser Med Vet. 2009;13(2):102-106.
Kirpensteijn J, Kik M, Rutteman GR, Teske E. Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet Pathol. 2002 Mar;39(2):240-246.
Mesquita L, Mortier J, Ressel L, Finotello R, Silvestrini P, Piviani M. Neoplastic pleural effusion and intrathoracic metastasis of a scapular osteosarcoma in a dog: a multidisciplinary integrated diagnostic approach. Vet Clin Pathol. 2017 Jun;46(2):337–343.
Takahashi TV, Mobricci LAL, Hyodo V, Duarte J. Feline Chondroblastic Osteosarcoma: Compa-rative Analysis by Pathology Tech-niques. FASEB J. 2020 Apr 20;34(1):1. doi: 10.1096/fasebj.2020.34.s1.04709.
Swieton N, Nykamp SG, Poirier V J, Wainberg S, Oblak ML. Suspected Radiation-Induced Osteosarcoma in a Domestic Shorthair Cat. Case Rep Vet Med. 2020 Jan 3; 1874342(1):1–6. doi: 10.1155/2020/1874342
Attar A, Ma K, Seham AAA, Adwak A. Chondroblastic Osteosar-coma in a Cat: Case Report. J Med Sur Pathol. 2016;1(4):1-4. doi:10.4172/2472-4971.1000137
Baum JI, Skinner OT, Boston SE. Fracture-associated osteosarcoma of the femur in a cat. Can Vet J. 2018 Oct;59(10):1096-1098.
Cowell RL, Tyler RD, Meinkoth JH, Denicola DB. Diagnóstico citológico e hematologia de cães e gatos. 3.ed. São Paulo: MedVet, 2009. 476p.
França RT, Schulz ÉT, Oliveira EC, Damarem WW, Giordani C, Pletsch JA, Sonne L. Fibroblastic osteosarcoma in a white-eared opossum (Didelphis albiventris). Pes Vet Bras. 2020;40(7):559-563. doi: 10.1590/1678-5150-PVB-6626.
Almela R, Von Bomhard W, Ansón A, Mayer U. Subcutaneous extraskeletal osteosarcoma in a metatarsal footpad in a cat. Vet Dermatol. 2017 Oct;28(5):524-e129. doi: 10.1111/vde.12461.
Olds JE, Derscheid RJ. Extraskeletal osteosarcoma in an Egyptian fruit bat (Rousettus aegyptiacus). Vet Rec Case Rep., 2018;6(2):e000579.
Craig LE, Dittmer KE, Thompson KG. Bone and joint. In: Jubb, Kennedy, and Palmer’s pathology of domestic animals, 6. ed. St Louis, MO: Elsevier, 2016, p. 16–163.
Grundmann E, Roessner A, Ueda Y, Schneider-Stock R, Radig K. Current aspects of the pathology of osteo-sarcoma. Anticancer Res. 1995 Mat-Jun;15(3)1023–1032.
Mueller F, Fuchs B, Kaser-Hotz B. Comparative biology of human and canine osteosarcoma. Anticancer Res. 2007 Jan-Feb;27(1A):155–164.
Dimopoulou M, Kirpensteijn J, Moens H, Kik M. Histologic Prognosticators in Feline Osteosarcoma: A Comparison with Phenotypically Similar Canine Osteosarcoma. Vet Surg. 2008 Jul;37(5):466–471.
Heldmann E, Anderson MA, Wagner-Mann C. Feline osteosarcoma: 145 cases (1990-1995). J Am Anim Hosp Assoc. 2000 Nov-Dec;36(6):518-521. doi: 10.5326/15473317-36-6-518.
Argyle DJ, Brearley MJ, Turek MM. Decision making in small animal oncology, 1st ed. Wiley Blackwell:USA, 2008.
Kuo TR, Chen CH. Bone biomarker for the clinical assessment of osteoporosis: Recent developments and future perspectives. Biomark Res. 2017 May 18;5(18):1-9. doi: 10. 1186/s40364-017-0097-4.
Hernández-Rodríguez NA, Correa E, Sotelo R, Contreras-Paredes A, Gomez-Ruiz C, Green L, Mohar A. Ki-67: a proliferative marker that may predict pulmonary metastases and mortality of primary osteosarcoma. Cancer Detect Prev. 2001;25(2):210–215.
Karsli B, Bakici M, Sumer T, Pekcan Z. Osteossarcoma Osteoblastic in a Cat. Intern J Vet Ani Res. 2021 May 22;4(1):27-29.
Giebels F, Forterre F, Vincenti S, Geissbuehler U, Welle MM, Pool R, Soldati S, Maiolini A. A complex histopathological challenge: suspicion of an osteoblastoma-like osteosarcoma arising from the second thoracic vertebra in a cat. BMC Vet Res. 2020 Oct 7;16(378):1-10. doi: 10.1186/s12917-020-02596-w.