Xanthogranulomatous Pyelonephritis: An Uncommon Form of Pyelonephritis Highlighted in a Case Report
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Abstract
Xanthogranulomatous pyelonephritis is a rare and aggressive variant of pyelonephritis, characterized by chronic granulomatous inflammation that progresses to destruction of the renal parenchyma and renal failure. Early diagnosis is a challenge. We present the case of a 7-year-old girl with high fever, associated with low back pain, anorexia and vomiting for 30 days. After antibiotic therapy, radical nephrectomy was required for definitive treatment. Due to its rare and aggressive nature, which often leads to the loss of the affected kidney, it is essential to alert healthcare professionals about the importance of early diagnosis to prevent disease progression and improve the patient's prognosis. We will use a case report to explore the clinical, radiological and pathological aspects related to xanthogranulomatous pyelonephritis.
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References
Mittal BV, Badhe BP. Xanthogranulomatous pyelonephritis (a clinicopathological study of 15 cases). J Postgrad Med. 1989 Oct;35(4):209-14. Erratum in: J Postgrad Med 1990 Apr;36(2):103. PMID: 2490367.
Hayes WS, Hartman DS, Sesterbenn IA. From the Archives of the AFIP. Xanthogranulomatous pyelonephritis. Radiographics. 1991 May;11(3):485-98. doi: 10.1148/radiographics.11.3.1852939. PMID: 1852939.
Zorzos I, Moutzouris V, Korakianitis G, Katsou G. Analysis of 39 cases of xanthogranulomatous pyelonephritis with emphasis on CT findings. Scand J Urol Nephrol. 2003;37(4):342-7. doi: 10.1080/00365590310004752. PMID: 12944195.
Jha SK, Aeddula NR. Xanthogranulomatous Pyelonephritis. 2024.
Osterlind S. Uber pyelonephritis xanthomatosa. Acta Chir Scand. 1944;369–76.
Harley F, Wei G, O'Callaghan M, Wong LM, Hennessey D, Kinnear N. Xanthogranulomatous pyelonephritis: a systematic review of treatment and mortality in more than 1000 cases. BJU Int. 2023 Apr;131(4):395-407. doi: 10.1111/bju.15878. Epub 2022 Sep 26. PMID: 35993745.
Jang TL, McKoy T, Hakim J, Polenakovik HM. Xanthogranulomatous pyelonephritis - A diagnostic and therapeutic dilemma. Am J Med Sci. 2023 Mar;365(3):294-301. doi: 10.1016/j.amjms.2022.11.004. Epub 2022 Dec 5. PMID: 36473546.
Sayed AG, Badghaish T, Abdo N, Nasir A. Diffuse Xanthogranulomatous pyelonephritis: A Rare Disease With A Common Presentation. Cureus. 2023 Aug 25;15(8):e44118. doi: 10.7759/cureus.44118. PMID: 37750147; PMCID: PMC10518206.
Deng QF, Chu H, Peng B, Liu X, Cao YS. Case report: Localized xanthogranulomatous pyelonephritis in children: A case report and literature review. Front Pediatr. 2022 Jul 18;10. Available from: https://www.frontiersin.org/articles/10.3389/fped.2022.952989/full
Malek RS, Elder JS. Xanthogranulomatous pyelonephritis: a critical analysis of 26 cases and of the literature. J Urol. 1978 May;119(5):589-93. doi: 10.1016/s0022-5347(17)57559-x. PMID: 660725.
Møller JC, Kristensen IB. Xanthogranulomatous pyelonephritis. A clinico-pathological study with special reference to pathogenesis. Acta Pathol Microbiol Scand A. 1980 Mar;88(2):89-96. PMID: 7368938.
Bkiri S, Abbad F, Ghadouane M. Xanthogranulomatous Pyelonephritis With Extension to the Liver: A Case Report. Cureus. 2023 Aug 4;15(8):e42929. doi: 10.7759/cureus.42929. PMID: 37667725; PMCID: PMC10475155.
Gravestock P, Moore L, Harding C, Veeratterapillay R. Xanthogranulomatous pyelonephritis: a review and meta-analysis with a focus on management. Vol. 54, International Urology and Nephrology. Springer Science and Business Media B.V.; 2022. p. 2445–56. https://doi.org/10.1007/s11255-022-03253-x.
Li L, Parwani A V. Xanthogranulomatous Pyelonephritis. Vol. 135, Arch Pathol Lab Med. 2011. p. 671–4.
Ostalska-Nowicka D, Mackowiak-Lewandowicz K, Konwerska A, Zachwieja J. Early Progression of Xanthogranulomatous Pyelonephritis in Children Might Be Dependent on Vimentin Expression. Am J Case Rep. 2017 Oct 5;18:1066-1072. doi: 10.12659/ajcr.904376. PMID: 28978905; PMCID: PMC5637626.
Korkes F, Favoretto RL, Bróglio M, Silva CA, Castro MG, Perez MD. Xanthogranulomatous pyelonephritis: clinical experience with 41 cases. Urology. 2008 Feb;71(2):178-80. doi: 10.1016/j.urology.2007.09.026. PMID: 18308077.
Bourm KS, Menias CO, Ali K, Alhalabi K, Elsayes KM. Spectrum of Xanthogranulomatous Processes in the Abdomen and Pelvis: A Pictorial Review of Infectious, Inflammatory, and Proliferative Responses. AJR Am J Roentgenol. 2017 Mar;208(3):475-484. doi: 10.2214/AJR.16.17075. Epub 2017 Jan 17. PMID: 28095017.
Kelly C, Anderson S, Looney A, Shannon N, Senaratne R, O'Connor E, Breen K, Lennon G, McGuire B, Murphy M, Moran D, Galvin D. Nephrectomy for xanthogranulomatous pyelonephritis-a not-so-simple solution. Ir J Med Sci. 2023 Aug 23. doi: 10.1007/s11845-023-03496-2. Epub ahead of print. PMID: 37610600.
Anand S, Tomar S, Jain V, Barwad A, Kandasamy D. Xanthogranulomatous pyelonephritis with nephrocutaneous fistula. J Pediatr Surg Case Rep. 2021 Jan;64:101674. doi: 10.1016/j.epsc.2020.101674.
Tamburrini S, Comune R, Lassandro G, Pezzullo F, Liguori C, Fiorini V, Picchi SG, Lugarà M, Del Biondo D, Masala S, Tamburro F, Scaglione M. MDCT Diagnosis and Staging of Xanthogranulomatous Pyelonephritis. Diagnostics (Basel). 2023 Apr 4;13(7):1340. doi: 10.3390/diagnostics13071340.
Al-Ghazo MA, Ghalayini IF, Matalka II, Al-Kaisi NS, Khader YS. Xanthogranulomatous pyelonephritis: Analysis of 18 cases. Asian J Surg. 2006 Oct;29(4):257-61. doi: 10.1016/S1015-9584(09)60099-3. PMID: 17098659.
Alenazi KA. Atypical Clinical Presentation of Xanthogranulomatous Pyelonephritis in a Female Child: A Case Report. Cureus. 2024 Feb 6; DOI: 10.7759/cureus.53666.
Chuang CK, Lai MK, Chang PL, Huang MH, Chu SH, Wu CJ, Wu HR. Xanthogranulomatous pyelonephritis: experience in 36 cases. J Urol. 1992 Feb;147(2):333-6. doi: 10.1016/s0022-5347(17)37229-4. PMID: 1732587.
Raziel A, Steinberg R, Kornreich L, Mor C, Golinsky D, Ziv N, Freud E, Zer M. Xanthogranulomatous pyelonephritis mim-icking malignant disease: is preservation of the kidney possible? Pediatr Surg Int. 1997 Sep;12(7):535-7. doi: 10.1007/BF01258721. PMID: 9238126.