Nephrotic syndrome and thymoma recurrence: a case report

Authors

DOI:

https://doi.org/10.52600/2763-583X.bjcr.2022.2.3.40-46

Keywords:

Glomerular disease, Minimal change disease, Nephrotic syndrome, Thymoma

Abstract

Paraneoplastic syndromes, such as myasthenia gravis, pure red-cell aplasia and systemic lupus erythematosus are well-documented in thymoma. Association with glomerulopathies is rare and may occur several years after thymectomy. We report a case of a 60-year-old male presenting with nephrotic syndrome after thymectomy due to thymoma. The kidney biopsy showed minimal change disease. The patient went into complete remission after treatment with corticosteroids. The pathogenesis of glomerular lesions associated with thymic disease remains controversial.

Author Biographies

Sara Vilela, Hospital Garcia de Orta

Hospital Garcia de Orta, Almada, Portugal.

Mariana Sousa, Hospital Garcia de Orta

Hospital Garcia de Orta, Almada, Portugal.

Gonçalo Cruz, Hospital Garcia de Orta

Hospital Garcia de Orta, Almada, Portugal.

Fernando Pereira, Hospital Garcia de Orta

Hospital Garcia de Orta, Almada, Portugal.

Pedro Bravo, Hospital Garcia de Orta

Hospital Garcia de Orta, Almada, Portugal.

References

Monga D, Jhaveri KD. Chapter 6: Glomerular Diseases and Cancer. Am Soc Nephrol. 2016;1–9. https://www.asn-online.org/education/distancelearning/curricula/onco/Chapter6.pdf.

Karras A, de Montpreville V, Fakhouri F, Grünfeld JP, Lesavre P, Dracon M, et al. Renal and thymic pathology in thymona-associated nephropathy: Report of 21 cases and review of the literature. Nephrol Dial Transplant. 2005;20 (March):1075–82.

Hsiao S-Y, Chang K-Y, Chang J-Y, Su W-C. Nephrotic Syndrome Associated with Thymoma. Táiwān Áizhèng Yīxué Zázhì [Internet]. The Chinese Oncology Society; 2014;1(3):233–40.

Mayrs EBC. The nephrotic syndrome. Br Med J. 1954;1(4856):273.

Nakamura T, Matsuyamat M, Kojimat A, Ogiut T, Kubota A, Suzuki Y. i The effect of thymectomy on the development of nephropathy in spontaneous thymoma rats of the BUF/Mna strain. 1988;350–2.

Downloads

Published

2022-06-11

Issue

Section

Clinical Case Reports

Categories