Chronic myeloid leukemia management during pregnancy: a case report

Authors

  • Luina Benevides Lima Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará https://orcid.org/0000-0001-6503-8657
  • Caroline de Fátima Aquino Moreira-Nunes Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará https://orcid.org/0000-0001-5845-3481
  • Felipe Pantoja Mesquita Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará
  • Lais Lacerda Brasil de Oliveira Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará https://orcid.org/0000-0003-2814-3575
  • Emanuel Cintra Austregésilo Bezerra Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará
  • Emerson Lucena da Silva Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará https://orcid.org/0000-0002-5761-8413
  • Fernando Barroso Duarte Department of Haematology, Walter Cantidio University Hospital, Federal University of Ceará
  • Acy Telles de Souza Quixadá Department of Haematology, Walter Cantidio University Hospital, Federal University of Ceará https://orcid.org/0000-0002-2146-7123
  • Maria Elisabete Amaral de Moraes Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará
  • Raquel Carvalho Montenegro Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará https://orcid.org/0000-0002-3861-293X

DOI:

https://doi.org/10.52600/2763-583X.bjcr.2022.2.3.47-53

Keywords:

Pregnancy, Chronic Myeloid Leukemia, Management

Abstract

Chronic Myeloid Leukemia (CML) is characterized by the increased and unregulated growth of myeloid cells in bone marrow and accumulation of these cells in blood. Its occurrence during pregnancy is a very rare condition and the correct management is not well stablished yet. We present a case of a 21-year-old female diagnosed with CML during pregnancy. The protocol chose by the doctor was hydroxyurea on second trimester, and interferon-alpha on third trimester. The baby was born healthy and at the expected time. After giving birth, the patient started Imatinib Mesilate (IM) 400mg/day treatment and was able to control the disease.

Author Biographies

Luina Benevides Lima, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Ceara, CE, Brazil.

Caroline de Fátima Aquino Moreira-Nunes, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceara, CE, Brazil.

Felipe Pantoja Mesquita, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Ceara, CE, Brazil.

Lais Lacerda Brasil de Oliveira, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Ceara, CE, Brazil.

Emanuel Cintra Austregésilo Bezerra, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Ceara, CE, Brazil.

Emerson Lucena da Silva, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Ceara, CE, Brazil.

Fernando Barroso Duarte, Department of Haematology, Walter Cantidio University Hospital, Federal University of Ceará

Department of Haematology, Walter Cantidio University Hospital, Federal University of Ceará, Ceará, CE, Brazil.

Acy Telles de Souza Quixadá, Department of Haematology, Walter Cantidio University Hospital, Federal University of Ceará

Department of Haematology, Walter Cantidio University Hospital, Federal University of Ceará, Ceará, CE, Brazil.

Maria Elisabete Amaral de Moraes, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Ceara, CE, Brazil.

Raquel Carvalho Montenegro, Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará

Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Ceara, CE, Brazil.

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Published

2022-06-11

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Clinical Case Reports

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