Frontoparietal cavernous malformation in a 39-year-old woman: a case report

Main Article Content

Camilla Costa Sallem
Beatriz Esmeraldo Teixeira
https://orcid.org/0000-0002-1165-4099
Caio Sérgio Gomes Sá
Lara Maria Fujita Vieira Lima
Letícia Passos Chaves Capibaribe Barros
Nayla Lima dos Santos
Halisson Rodrigues de Andrade
Tulia Fernanda Meira Garcia
Felipe Rios Moraes Andrade de Alencar
Álvaro Moreira Rivelli Rivelli
Júlio César Claudino dos Santos

Abstract

Cerebral cavernous malformation (CCMs) is an angiographically occult, low-flow neurovascular disease resulting from capillary dilatation of cerebral blood vessels that may also occur in the spinal cord, causing extravasation of blood cells from the affected vessel that leads to multiple repercussions in the patient’s life. This condition’s clinical characteristics include recurrent bleeding, seizures, persistent neurological deficits, epilepsy, and death. In this study, we describe the clinical course of a patient with a Cavernous Malformation and its prognosis regarding the association between clinical progression and therapeutic perspectives. It's relevant to elucidate possible lack of studies that may urge further research on this theme and new learning pathways should be opted for to increase awareness of this condition in order to improve its prognosis.

Article Details

How to Cite
Sallem, C. C., Teixeira, B. E., Sá, C. S. G., Lima, L. M. F. V., Barros, L. P. C. C., Santos, N. L. dos, Andrade, H. R. de, Garcia, T. F. M., Alencar, F. R. M. A. de, Rivelli, Álvaro M. R., & Santos, J. C. C. dos. (2023). Frontoparietal cavernous malformation in a 39-year-old woman: a case report. Brazilian Journal of Case Reports, 4(1), 16–20. https://doi.org/10.52600/2763-583X.bjcr.2024.4.1.16-20
Section
Clinical Case Reports
Author Biographies

Camilla Costa Sallem, Christus University Center (UNICHRISTUS)

Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.

Beatriz Esmeraldo Teixeira, Christus University Center (UNICHRISTUS)

Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.

Caio Sérgio Gomes Sá, Christus University Center (UNICHRISTUS)

Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.

Lara Maria Fujita Vieira Lima, Christus University Center (UNICHRISTUS)

Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.

Letícia Passos Chaves Capibaribe Barros, Christus University Center (UNICHRISTUS)

Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.

Nayla Lima dos Santos, Christus University Center (UNICHRISTUS)

Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.

Halisson Rodrigues de Andrade, Division of Neurosurgery, Department of Surgery, Santa Casa de São Paulo School of Medical Sciences (FCMSCSP)

Division of Neurosurgery, Department of Surgery, Santa Casa de São Paulo School of Medical Sciences (FCMSCSP), São Paulo-SP, Brazil.

Tulia Fernanda Meira Garcia, Multicampi School of Medical Sciences, Federal University of Rio Grande do Norte

Multicampi School of Medical Sciences, Federal University of Rio Grande do Norte, Caicó, RN,

Felipe Rios Moraes Andrade de Alencar, State University of Health Sciences of Alagoas (UNCISAL)

State University of Health Sciences of Alagoas (UNCISAL), Maceió, AL, Brazil.

Álvaro Moreira Rivelli Rivelli, Governador Ozanam Coelho University Center, UNIFAGOC

Governador Ozanam Coelho University Center, UNIFAGOC, Ubá, Belo Horizonte, Minas Gerais, Brazil.

Júlio César Claudino dos Santos, Christus University Center (UNICHRISTUS)

Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.

University of Sao Paulo, Sao Paulo, SP, Brazil.

Morphology Department of the Federal University of Ceará - UFC, Fortaleza, CE, Brazil.

References

Awad IA, Polster SP. Cavernous angiomas: deconstructing a neurosurgical disease. J Neurosurg. 2019 Jul 1;131(1):1-13. doi: 10.3171/2019.3.JNS181724. PMID: 31261134; PMCID: PMC6778695.

McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IA. A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. Transl Stroke Res. 2020 Jun;11(3):365-376. doi: 10.1007/s12975-019-00725-8. Epub 2019 Aug 24. PMID: 31446620; PMCID: PMC7036327.

Flemming KD, Kumar S, Brown RD Jr, Lanzino G. Predictors of Initial Presentation with Hemorrhage in Patients with Cavernous Malformations. World Neurosurg. 2020 Jan;133:e767-e773. doi: 10.1016/j.wneu.2019.09.161. Epub 2019 Oct 9. PMID: 31605843.

Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L. Familial Cerebral Cavernous Malformations. Stroke. 2019 May;50(5):1294-1301. doi: 10.1161/STROKEAHA.118.022314. PMID: 30909834; PMCID: PMC6924279.

Flemming KD, Kumar S, Brown RD Jr, Lanzino G. Predictors of Initial Presentation with Hemorrhage in Patients with Cavernous Malformations. World Neurosurg. 2020 Jan;133:e767-e773. doi: 10.1016/j.wneu.2019.09.161. Epub 2019 Oct 9. PMID: 31605843.

Batra S, Lin D, Recinos PF, Zhang J, Rigamondi D. Cavernous Malformations: Natural history, diagnosis and treatment. Nature Rev Neurol, v. 5, n. 12, p. 659-670, Dez. 2009.

Flemming KD, Kumar S, Brown RD Jr, Lanzino G. Predictors of Initial Presentation with Hemorrhage in Patients with Cavernous Malformations. World Neurosurg. 2020 Jan;133:e767-e773. doi: 10.1016/j.wneu.2019.09.161. Epub 2019 Oct 9. PMID: 31605843.

Shervin Taslimi, MD, MPH Amirhossein Modabbernia, MD Sepideh Amin- Hanjani,MD, Fred G. Barker II, MDR. Loch Macdonald, MD.: Natural history of cavernous malformation: Systematic review and meta-analysis of 25 studies Neurology 2016;86:1984–1991.

Torres G, Kini AT, Al Othman B, Lee AG. Familial Cavernous Hemangioma. J Neuroophthalmol. 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269.

Labauge P, Denier C, Bergametti F, Tournier-Lasserve E. Genetics of Cavernous Angiomas. Lancet Neurol, v. 6, n. 3, p. 237-244, Mar. 2007.

Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L. Familial Cerebral Cavernous Malformations. Stroke. 2019 May;50(5):1294-1301. doi: 10.1161/STROKEAHA.118.022314. PMID: 30909834; PMCID: PMC6924279.

Dalyai RT, Ghobrial G, Awad I, et al. Management of incidental cavernous malformations: a review. Neurosurg Focus. 2011;31(6):E5. doi:10.3171/2011.9.FOCUS11211.

Al Barbarawi MM, Asfour HA, Qudsieh SM, et al. Isolated tectal cavernomas: A comprehensive literature review with a case presentation. Heliyon. 2022;8(4):e09244. Published 2022 Apr 5. doi:10.1016/j.heliyon.2022.e09244

Chen CJ, Ding D, Derdeyn CP, Lanzino G, Friedlander RM, Southerland AM, Lawton MT, Sheehan JP. Brain arteriovenous malformations: A review of natural history, pathobiology, and interventions. Neurology. 2020 Nov 17;95(20):917-927. doi: 10.1212/WNL.0000000000010968. Epub 2020 Oct 1. PMID: 33004601.

Blitstein M & Tung G. MRI of Cerebral Microhemorrhages. AJR Am J Roentgenol. 2007;189(3):720-5. doi:10.2214/ajr.07.2249

Expert Panel on Neurologic Imaging: Salmela MB, Mortazavi S, Jagadeesan BD, Broderick DF, Burns J, Deshmukh TK, Harvey HB, Hoang J, Hunt CH, Kennedy TA, Khalessi AA, Mack W, Patel ND, Perlmutter JS, Policeni B, Schroeder JW, Setzen G, Whitehead MT, Cornelius RS, Corey AS. ACR Appropriateness Criteria®Cerebrovascular Disease. J Am Coll Radiol. 2017 May;14(5S):S34-S61.

Gross BA, Lin N, Du R, Day AL. The natural history of intracranial cavernous malformations. Neurosurg Focus. 2011 Jun;30(6):E24.

Petersen TA, Morrison LA, Schrader RM, Hart BL. Familial versus sporadic cavernous malformations: differences in devel-opmental venous anomaly association and lesion phenotype. AJNR Am J Neuroradiol. 2010 Feb;31(2):377-82.

Dammann P, Wrede K, Zhu Y, Matsushige T, Maderwald S, Umutlu L, Quick HH, Hehr U, Rath M, Ladd ME, Felbor U, Sure U. Correlation of the venous angioarchitecture of multiple cerebral cavernous malformations with familial or sporadic disease: a susceptibility-weighted imaging study with 7-Tesla MRI. J Neurosurg. 2017 Feb;126(2):570-577.

Most read articles by the same author(s)