A Clinical Odyssey: a case report on the diagnostic complexity and neurological management of Behçet's disease
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Abstract
Behcet's Syndrome (BS) is a pathological condition that encompasses a diverse spectrum of clinical manifestations of a polysystemic nature. It is a chronically progressive inflammatory vasculitis, characterized mainly by recurrent episodes of oral and genital aphthous ulcers, ocular involvement, and other clinical expressions, including skin lesions and gastrointestinal disorders. The aim of this study is to present an atypical case of BS, as well as its correlation with the medical literature, to elucidate particularities of relevant significance for medical practice.
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References
Hatemi G, Seyahi E, Fresko I, Talarico R, Hamuryudan V. One year in review 2020: Behçet's syndrome. Clin Exp Rheumatol. 2020;38 Suppl 127(5):3–10.
Yurdakul S. Epidemiology of Behçet Syndrome and Regional Differences in Disease Expression. In: Yazici Y, Hatemi G, Seyahi E, Yazici H, editors. Behçet Syndrome. Springer, Cham; 2020. https://doi.org/10.1007/978-3-030-24131-5.
Kidd DP. Neurological complications of Behçet's syndrome. J Neurol. 2017;264(10):2178–2183.
Noel N, Bernard R, Wechsler B, Resche-Rigon M, Depaz R, Le Thi Huong Boutin D, et al. Long-term outcome of neuro-Behçet's disease. Arthritis Rheumatol. 2014;66(5):1306–1314.
Domingos J, Ferrão C, Ramalho J, Rodrigues T, Moreira B, Santos E, et al. Characteristics of neuro-Behçet's disease in a case-series from a single centre in Northern Portugal. Eur Neurol. 2015;73(5-6):321–328.
Saadoun D, Cassoux N, Wechsler B, Boutin D, Terrada C, Lehoang P, Bodaghi B, Cacoub P. Ocular manifestations of Behcet's disease. Rev Med Interne. 2010;31(8):545–550. doi: 10.1016/j.revmed.2009.04.014.
Saadoun D, Wechsler B. Behçet's disease. Orphanet J Rare Dis. 2012 Apr 12;7:20. doi: 10.1186/1750-1172-7-20.
Martín-Varillas JL, Calvo-Río V, Beltrán E, Sánchez-Bursón J, Mesquida M, Adán A, et al. Successful Optimization of Ada-limumab Therapy in Refractory Uveitis Due to Behçet's Disease. Ophthalmology. 2018;125(9):1444-51.
Owlia MB, Mehrpoor G. Behcet's Disease: New Concepts in Cardiovascular Involvements and Future Direction for Treatment. ISRN Pharmacol. 2012;2012:760484. doi: 10.5402/2012/760484.
Silva L, Correia J, Santos E. Diagnóstico e Tratamento de Neuro-Behçet: Uma Atualização Clínica. Porto Acta Med [Internet]. 2023, 21 de junho [citado em 26 de agosto de 2023]. Disponível em: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19734.
Borhani-Haghighi A, Kardeh B, Banerjee S, Yadollahikhales G, Safari A, Sahraian MA, Shapiro L. Neuro-Behcet's disease: An update on diagnosis, differential diagnoses, and treatment. Mult Scler Relat Disord. 2020 Apr;39:101906. doi: 10.1016/j.msard.2019.101906. Epub 2019 Dec 23. PMID: 31887565.
Yazici H, Fresko I, Yurdakul S. Behçet: manifestações da doença, manejo e avanços no tratamento. Nat Clin Pract Reumatol. 2007;3(3):148-155.
Sachdev N, Kapali N, Singh R, Gupta V, Gupta A. Espectro da doença de Behçet na população indiana. Int Oftalmol. 2009;29(6):495-501.
Kidd D, Steuer A, Denman AM, Rudge P. Neurological complications in Behçet’s syndrome. Brain. 1999;122(Pt 11):2183-94.
Kanski JJ. Clinical ophthalmology. Uveitis (6): 3rd ed.
Yazici H, Pazarli H, Barnes CG, Tuzun Y, Ozyazgan Y, Silman A, Serdaroglu S, Oguz V, Yurdakul S, Lovatt GE et al. A controlled trial of azathioprine in Behçet’s syndrome. N Engl J Med. 1990;322:281-5.
Yazici H, Yurdakul S, Hamuryudan V. Behçet’s syndrome. Curr Opin Rheumatol. 1999;11:53-7.
Borhani-Haghighi A, Kardeh B, Banerjee S, Yadollahikhales G, Safari A, Sahraian MA, Shapiro L. Neuro-Behcet's disease: an update on diagnosis, differential diagnoses, and treatment. Multiple sclerosis and related disorders. 2020;39:101906.
Confavreux C, Saddier P, Grimaud J, Moreau T, Adeleine P, Aimard G. Risk of cancer from azathioprine therapy in multiple sclerosis: a case-control study. Neurology. 1996;46(6):1607-1612.
Hirohata S, Kikuchi H. Behçet’s disease. Arthritis Res Ther. 2003;5(3):139-46.
Yurdakul S, Mat C, Tüzün Y, Ozyazgan Y, Hamuryudan V, Uysal O, et al. A double-blind trial of colchicine in Behçet’s syn-drome. Arthritis Rheum. 2001;44(11):2686-92.
Davatchi F, Sadeghi Abdollahi B, Tehrani Banihashemi A, Shahram F, Nadji A, Shams H, et al. Colchicine versus placebo in Behçet’s disease: randomized, double-blind, controlled crossover trial. Mod Rheumatol. 2009;19(5):542-9.
Caruso P, Moretti R. Focus on neuro-Behçet's disease: A review. Neurol India. 2018 Nov-Dec;66(6):1619-1628. doi: 10.4103/0028-3886.246252.