Clinical, Neurophysiological and Histopatological correlations in Pure Neural Leprosy

Authors

  • Izabela Jardim Rodrigues Pitta Universidade Federal do Estado do Rio de Janeiro https://orcid.org/0000-0001-8370-6065
  • Bruno de Siqueira Mietto Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora
  • Aron dos Santos Camilo Universidade do Estado do Rio de Janeiro (UERJ)
  • Sergio Luiz Gomes Antunes Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz)
  • Euzenir Nunes Sarno Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz)
  • Marcia Rodrigues Jardim Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz)

DOI:

https://doi.org/10.52600/2763-583X.bjcr.2021.1.4.105-113

Keywords:

Leprosy, Neuropathy, Ulnar Neuropathy, Nerve Conduction Studies

Abstract

Although neuropathy remains one of the most problematic issues faced by leprosy patients, the evolving process of its findings continues a challenge particularly in pure neural leprosy (PNL). We evaluated neurological examination, nerve conduction studies and histhopathological data of patients with PNL and ulnar neuropathy. Patients with longer duration of symptoms had reduction in the motor conduction velocities and patients with fibrosis in the biopsy had axonal damage in the nerve conduction studies. This suggests that focal demyelination may be present in leprosy patients at the moment of the diagnosis and be related to the duration of the neuropathy.

Author Biographies

Izabela Jardim Rodrigues Pitta, Universidade Federal do Estado do Rio de Janeiro

Programa de Pós Graduação em Neurologia (PPGNeuro), Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, RJ, Brazil.

Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.

Universidade do Estado do Rio de Janeiro, UERJ, Rio de Janeiro, RJ, Brazil.

Bruno de Siqueira Mietto, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora

Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.

Aron dos Santos Camilo, Universidade do Estado do Rio de Janeiro (UERJ)

Universidade do Estado do Rio de Janeiro, UERJ, Rio de Janeiro, RJ, Brazil.

Sergio Luiz Gomes Antunes, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz)

Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.

Euzenir Nunes Sarno, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz)

Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.

Marcia Rodrigues Jardim, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz)

Programa de Pós Graduação em Neurologia (PPGNeuro), Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, RJ, Brazil.

Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.

Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.

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Published

2021-11-05

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Experimental Reports

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