Lymphedema due to Podoconiosis in Brazil
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Abstract
Podoconiosis is a neglected tropical disease that causes a type of progressive, non-infectious tropical lymphedema. Aim: The aim is reported one case of the one woman that presented always having problems with allergies and “lumps” appeared on the hallux of the right foot; it resembled a callus, which never disappeared and increased in size. The physical exam revealed several hardened nodular lesions in both feet involving the soles. The patient was submitted to intensive treatment for lymphedema using the Godoy Method® for the lower limbs for five days. The nodules were hardened and constant from the beginning. However, intensive treatment led to a reduction in the volume of the lesions, enabling better plantar flexion and extension as well as a gain in ambulation. However, the characteristics of the evolution of the condition, symptoms and the occurrence of nodules on velvety skin with a mossy kept appearance because are characteristics of podoconiosis. Podoconiosis may have other causes beyond those reported in literature, likely related to the exposure of the limb and associated immunological abnormalities.
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References
Douglass J, Hailekiros F, Martindale S, Mableson H, Seife F, Bishaw T, et al. Addition of Lymphatic Stimulating Self-Care Practices Reduces Acute Attacks among People Affected by Moderate and Severe Lower-Limb Lymphedema in Ethiopia, a Cluster Randomized Controlled Trial. J Clin Med. 2020 Dec 17;9(12):4077. doi: 10.3390/jcm9124077. PMID: 33348721; PMCID: PMC7766500.
Davey G, Bockarie M, Wanji S, Addiss D, Fuller C, Fox L, et al. Launch of the international podoconiosis initiative. Lancet. 2012 Mar 17;379(9820):1004. doi: 10.1016/S0140-6736(12)60427-9. PMID: 22423883.
Yimer M, Hailu T, Mulu W, Abera B. Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. J Vector Borne Dis. 2015 Jun;52(2):111-5. PMID: 26119541.
Gebresilase T, Finan C, Suveges D, Tessema TS, Aseffa A, Davey G, et al. Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups. Sci Rep. 2021 Feb 8;11(1):3285. doi: 10.1038/s41598-021-81836-x. PMID: 33558538; PMCID: PMC7870958.
Dejene F, Merga H, Asefa H. Community based cross sectional study of podoconiosis and associated factors in Dano district, Central Ethiopia. PLoS Negl Trop Dis. 2019 Jan 28;13(1):e0007050. doi: 10.1371/journal.pntd.0007050. PMID: 30689654; PMCID: PMC6366781.
Deribe K, Brooker SJ, Pullan RL, Sime H, Gebretsadik A, Assefa A, et al. Epidemiology and individual, household and geo-graphical risk factors of podoconiosis in Ethiopia: results from the first nationwide mapping. Am J Trop Med Hyg. 2015 Jan;92(1):148–58. http://dx.doi.org/10.4269/ajtmh.14-0446 pmid: 25404069
Price EW. Endemic elephantiasis: early signs and symptoms, and control. Ethiop Med J. 1983 Oct;21(4):243–53. pmid: 6628370
Deribe K, Wanji S, Shafi OM, Tukahebwa E, Umulisa I, Molyneux DH, et al.The feasibility of eliminating podoconiosis. Bull World Health Organ. 2015 Oct 1;93(10):712-718. doi: 10.2471/BLT.14.150276. Epub 2015 Aug 21. PMID: 26600613; PMCID: PMC4645432.
Tekola F, Bull S, Farsides B, Newport MJ, Adeyemo A, Rotimi CN, et al. Impact of social stigma on the process of obtaining informed consent for genetic research on podoconiosis: a qualitative study. BMC Med Ethics. 2009 Aug 22;10:13. doi: 10.1186/1472-6939-10-13. PMID: 19698115; PMCID: PMC2736170.
Alemnew B, Fasil A, Mulatu T, Bililign N, Esthetie S, Demis A. Epidemiology of podoconiosis in Ethiopia: a systematic review and meta-analysis protocol. BMJ Open. 2020 Jan 7;10(1):e032850. doi: 10.1136/bmjopen-2019-032850. PMID: 31915168; PMCID: PMC6955535.
Tekola Ayele F, Adeyemo A, Finan C, Hailu E, Sinnott P, Burlinson ND, et al. HLA class II locus and susceptibility to podo-coniosis. N Engl J Med 2012;366(13):1200–8. doi: 10.1056/NEJMoa1108448
Tada MS, Marsden PD. Probable podoconiosis in Brasilia. Rev Soc Bras Med Trop. 1993 Oct-Dec;26(4):255. doi: 10.1590/s0037-86821993000400011.
Pereira de Godoy JM, Guerreiro Godoy MF, Barufi S, Pereira de Godoy HJ. Intensive Treatment of Lower-Limb Lymphedema and Variations in Volume Before and After: A Follow-Up. Cureus. 2020 Oct 1;12(10):e10756. doi: 10.7759/cureus.10756. PMID: 33033665; PMCID: PMC7532877.
Pereira de Godoy HJ, Budtinger Filho R, Godoy MF, de Godoy JM. Evolution of Skin during Rehabilitation for Elephantiasis Using Intensive Treatment. Case Rep Dermatol Med. 2016;2016:4305910. doi: 10.1155/2016/4305910. Epub 2016 Nov 24. PMID: 27999691; PMCID: PMC5143703.
Pereira de Godoy AC, Guerreiro Godoy MF, Pereira de Godoy LM, Pereira de Godoy HJ, Pereira de Godoy JM. Intensive Treatment for Upper Limb Lymphedema. Cureus. 2021 Sep 16;13(9):e18026. doi: 10.7759/cureus.18026. PMID: 34540515; PMCID: PMC8448274.
Pereira de Godoy HJ, Pereira de Godoy AC, Lopes Pinto R, Baruffi S, Pereira de Godoy JM, Guerreiro Godoy MF. Mechanical lymphatic therapy to maintain the results of treatment for lymphedema. Acta Phlebol 2021;22:51-4. DOI: 10.23736/S1593-232X.21.00489-6
Pereira de Godoy JM, Guerreiro Godoy MF, Pereira de Godoy HJ, De Santi Neto D. Stimulation of Synthesis and Lysis of Extracellular Matrix Proteins in Fibrosis Associated with Lymphedema. Dermatopathology (Basel). 2021 Dec 28;9(1):1-10. doi: 10.3390/dermatopathology9010001. PMID: 35076482; PMCID: PMC8788559.
Pereira de Godoy JM, Pereira de Godoy LM, de Fatima Guerreiro Godoy M, Neto DS. Physiological Stimulation of the Synthesis of Preelastic Fibers in the Dermis of a Patient with Fibrosis. Case Rep Med. 2021 Dec 30;2021:2666867. doi: 10.1155/2021/2666867. PMID: 35003267; PMCID: PMC8739906
Pereira de Godoy JM, Pereira de Godoy AC, Guerreiro Godoy MF, et al. Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report. Dermatopathology (Basel); v.10, n.1, p.104-111, 2023 Mar 9. doi: 10.3390/dermatopathology10010016.