Bilateral ovarian dysgerminoma with metastasis in female dog's mesenteric lymph node: a case report
Article Sidebar
Main Article Content
Abstract
Dysgerminoma is a rare malignant neoplasm, associated with hormonal dysfunctions, which occurs in canine and feline females from middle age to elderly, without racial predisposition. In the present report, we described a case of ovarian dysgerminoma in a dog, only abdominal distension, persistent vulvar bloody discharge and apathy. The animal in question underwent exploratory laparotomy, where general neoformations were detected in the ovaries, and a lymph node with abnormal characteristics was also found. Therefore, surgery for ovariosalpingoisterectomy and puncture of a fragment of the lymph node altered for incisional biopsy was performed. The diagnosis was made through histopathological examination of the ovaries of the fragment derived from the lymph node, the result of which indicated the presence of dysgerminoma in both ovaries and in the lymph node, characterizing a metastasis. In view of this result, the chemotherapy protocol with the association of carboplatin and vinblastine was instituted, which proved to be effective and not very toxic to the animal, with no clinical sign of metastasis being identified after its use.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Wellons JC, Reddy AT, Tubbs RS, Abdullatif H, Oakes WJ, Blount JP, Grabb PA. Neuroendoscopic findings in patients with intracranial germinomas correlating with diabetes insipidus. J Neurosurg. 2004 May;100(5 Suppl Pediatrics):430-6.
Klein MK. Tumors of the female reproductive system. In: Witrow SJ, Macwewen EG. Small Animal Clinical Oncology . Ed. W.B. Saundes Company. Philadelphia, p. 445- 453, 2001.
Fernández T, Díez Bru N, Riso A, Gómez L, Pumarola M. Intracranial metastasis from a ovarian disgerminoma in a 2-year-old dog. J. Am. Hosp. Assoc, 2001.
Morris J, Dobson J. Small Animal Oncology. Editora Blackwell Science. Oxford, p. 166-183, 2001.
Bustamante RI, Martinís ES, Díaz GR, Carinõ CR, Ascanio E. Tumores de células germinales primarias de ovário em perras. Revista Científica. 1999, 9(1):40-46.
Grooters AM. Ovariopatias e uteropatias. In: Birchard JS, Sherding RG. Clínica de Pequenos Animais. 1 ed. São Paulo: Roca, p. 1002-1015, 1998.
O’keefe DA. Tumores do Sistema Genital e das Glândulas Mamárias. In: Ettinger SJ, Feldman EC. Tratado de Medicina Interna Veterinária. 4 ed. São Paulo, Manole Ltda., p. 2344-2351, 1997.
Cotran RS, Kumar V, Robbins SL. Female Genital Tract In: Pathologic Basis of Disease. 5.ed, WB Sauders Company, 1992;1073-1074.
Dune ACC, Bechara GH. Disgerminoma unilateral em cadela. Acta Scientiae Veterinariae, 2007:1333-1334.
North S, Banks T. Tumor of urogenital tract. In: Introduction to small animal oncology. Editora Elsevier, p. 150-171, 2009.
Greenlee PG, Patnaik AK. Canine Ovarian Tumors of Germ Cell Origin, Vet. Pathol. 1985; 22:117-122.
Nielsen SW, Kennedy PC. Tumors of the genital system. In: Moulton, J. E. Tumors in Domestic Animals. University of California Press, Berkeley, 3ª ed., p. 479–517, 1990.
Brewer BM, Gershenson DM, Herzog CE, Mitchell MF, Silva EG, Wharton JT. Outcome and reproductive function after chemotherapy for ovarian disgerminoma. Journal of Clinical Oncology, 1999; 17(9):2670-75.
Scullyr E. Tumors of the ovary and maldeveloped gonads. AFIP Fascicle, Nº 16, Armed Forces Institute of Pathology, Bethesda, p. 246, 1982.
Smith CW. Dysgerminoma in a dog: a case report. J Am Anim Hosp Assoc, 1973:585-587.
Britt JOJR, Howard BE. An ovarian teratoma in a dog. Canine Pract., 1981;8:41-44.
Owen LN. TNM Classification of tumours in domestics Animals. World Health Organisation. Genebra. 1980.
Jones TC, Hunt RD, King NW. Patologia Veterinária. 6ª edição, editora Manole, p. 1179-1183, 2000.
Abelleira R, González R, Pérez JR, Rivera A, Álvarez JC. Tumores de células germinales del ovario: disgerminoma y gonadoblastoma. Prog Obstet Ginecol, 2006: 526-531.
Kumar S, Shah JP, Bryant CS, Imudia AN, Cote ML; et al. The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. Gynecol Oncol., 2008:125–132.
Klein MK. Tumors of female reproductive system. In: Witrow, S.J.; Macwewen, E.G. Small Animal Clinical Oncology. Canada: Saunders Elsevier, 4th ed., p.610-618, 2007.
Maclachlan NJ, Kennedy PC. Tumors of the Genital Systems. In: Meuten, D. J. Tumors in Domestic Animals. Fourth Edition, Iowa State Press, 2002.
Andrews EJ, Stookey JL, Helland DR, Slaughtor LJ. A Histopathological study of canine and feline ovarian dysgerminomas. Can. J. Comp. Med., 1974; 38: 85-89.
Ibáñez E, Rodríguez-Escudero FJ. Tratado de Ginecología, Obstetricia y Medicina de la Reproducción. Madrid, Panamericana., 2003:1637-1639.
Jeyakumar A, Cabeza R, hindenburg A. Late recurrence in ovarian dysgerminoma with successful response to standard adjuvant chemotherapy: a case report and review of the literature. Gynecol Oncol., 2001:314-317.
Markman M, Kennedy A, Webster K, Elson P, Peterson G, Kulp B, Belinson J. Clinical features of hypersensitivity reactions to carboplatin. J. Clin. Oncol.,1999; 17:1141–1145.
Chun R, Garret L, Macewven EG. Cancer Chemoteryapy In: Witrow, S.J.; Macwewen, E.G. Small Animal Clinical Oncology. Ed. W.B. Saundes Company, Philadelphia, p. 92-118, 2001.