Association of Diabetes Mellitus and Pancreatic Cancer: Literature Review
Article Sidebar
Main Article Content
Abstract
Despite the metabolic activity, especially related to endocrinological disease, diabetes mellitus seems to be intrinsically associated with pancreatic cancer, studies in this line of research are still limited and without a detailed description of the disorders that confirm the association between them. Thus, the present study aims, in essence, through the literature review method, to present the association of pancreatic neoplasia and diabetes mellitus, seeking to evaluate the mechanism of association between the endocrinological presentation studied as a causality factor or possible consequence in the face of the neoplasm condition, as well as evaluating the possibility of screening, according to associative confirmation, of patients with diabetes mellitus in relation to the development of pancreatic cancer, considering that this neoplasm has one of the highest mortality rates ever described in the literature.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Ducreux, M., Cuhna, A. S., Caramella, C., Hollebecque, A., Burtin, P., Goéré, D. Arnold, D. (2015). Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 26(suppl 5), v56–v68. doi:10.1093/annonc/mdv295
Instituto Nacional de Câncer. Ministério da Saúde. Secretaria de Atenção à Saúde. Estimativas 2008: incidência do câncer no BrasilRio de Janeiro: INCA; 2007.
Camila Sayuri Horita Alves da Silva et.al. Adenocarcinoma de pâncreas em paciente jovem: relato de caso.Arq Med Hosp Fac Cienc Med Santa Casa São Paulo 2011; 56(1):36-9 1.
Malvezzi M, Bertuccio P, Levi F et al. European cancer mortality predictions for the year 2014. Ann Oncol 2014; 25: 1650–1656.
Yeo TP. Demographics, epidemiology, and inheritance of pancreatic ductal adenocarcinoma. Semin Oncol 2015; 42: 8–18.
Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7–34. doi:10.3322/caac.21551
Maisonneuve P, Lowenfels AB. Risk factors for pancreatic cancer: a summary review of meta-analytical studies. Int J Epidemiol 2015; 44: 186–198.
Golan, T., Hammel, P., Reni, M., Van Cutsem, E., Macarulla, T., Hall, M. J. Kindler, H. L. (2019). Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. New England Journal of Medicine. doi:10.1056/nejmoa1903387
J. Li, G. Cao, Q. Ma, H. Liu, W. Li, L. Han, The bidirectional interation between pancreatic cancer and diabetes, World J. Surg. Oncol. 10 (2012) 171.
DAI, X. et al. Altered profile of serum microRNAs in pancreatic cancer-associated new-onset diabetes mellitus. Journal of Diabetes, v. 8, n. 3, p. 422-433, 2016.
Neoptolemos JP, Palmer DH, Ghaneh P, et al: Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): A multicentre, open-label, randomised, phase 3 trial. Lancet 389(10073):1011–1024, 2017. doi: 10.1016/S0140-6736(16)32409-6
LU, Y. et al. New-onset type 2 diabetes, elevated HbA1c, anti-diabetic medications, and risk of pancreatic cancer. British Journal of Cancer, v. 113, n. 11, p. 1607-14, 2015.
Gullo L, Pezzilli R, Morselli-Labate AM, and The Italian Pancreatic Cancer Study Group. Diabetes and the risk of pancreatic cancer. N Engl J Med 1994;331:81-4.
Chow WH, Gridley G, Nyrén O, Linet MS, Ekbom A, Fraumeni JF, et al. Risk of pancreatic cancer following diabetes mellitus: A Nationwide Cohort Study in Sweden. J Natl Cancer Inst 1995;87:930-1.
Kasakoff K, Cardeza T, Liu J, Adrian TE, Bagchi D, Bagchi M, et al. Effects of voluntary physical exercise on high-fat diet-promoted pancreatic carcinogenesis in hamster model. Nutr Cancer 1996;26:265-79.
Schneider MB, Matsuzaki H, Haorah J, Ulrich A, Standop J, Ding XZ, et al. Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 2001;120:1263-70
DUAN, Xiaoye et al. Diabetes Mellitus tipo 2 se cruza com o diagnóstico e desenvolvimento do câncer de pâncreas. Frontal Oncol, [s. l.], v. 11, ed. 730038, p. 1-9, 2021.
Frye JNR, Inder WJ, Dobbs BR, Frizelle FA. Pancreatic cancer and diabetes: Is there a relationship? A case-controlled study. Aust NZ J Surg 2000;70:722-4.
DUGNANI, E. et al. Diabetes associated with pancreatic ductal adenocarcinoma is just diabetes: Results of a prospective observational study in surgical patients. Pancreatology, v. 16, n. 5, p. 844- 852, 2016.
] D. Li, Y. Mao, P. Chang, C. Liu, M.M. Hassan, S.J. Yeung, J.L. Abbruzzese, Impacts of new-onset and long-term diabetes on clinical outcome of pancreatic cancer, Am. J. Canc. Res. 5 (10) (2015) 3260–3269.
A. Pereira. Dibetes Mellitus e Carcinoma Ductal de Pancreas. Caso Especial • Arq Bras Endocrinol Metab 46 (6) • Dez 2002 • https://doi.org/10.1590/S0004-27302002000600014
Permert J, Ihse I, Jorfeldt L, von Schenck H, Arnquist HJ, Larsson J. Pancreatic cancer is associated with impaired glucose metabolism. Eur J Surg 1993;159:101-7.
Permert J, Ihse I, Jorfeldt L, von Schenck H, Arnquist HJ, Larsson J. Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer. Br J Surg 1993;80:1047-50.
Permert J, Larsson J, Fruin AB, Tatemoto K, Herrington MK, von Schenck H, et al. Islet hormone secretion in pancreatic cancer patients with diabetes. Pancreas 1997;15:60-8.