Mycobacterium abscessus subsp. massiliense infection secondary to traumatic anterior cruciate ligament reconstruction surgery

Main Article Content

Christopher P. Emerson
Hogan Brecount
Daniel Quintero
Dylan N. Greif
Jean Jose
Lee Kaplan

Abstract

Non-tuberculous Mycobacterium (NTM) infections following knee surgery are rarely reported in the literature. One month after arthroscopic lysis of adhesions from anterior cruciate ligament (ACL) reconstruction, a 67-year-old male patient presented with symptoms suggesting septic arthritis. Empiric antibiotics were initiated. Intraoperative cultures were positive for Mycobacterium abscessus. Organism-specific antimicrobial therapy with azithromycin, amikacin, and imipenem were started. Four months later the patient was switched to oral outpatient treatment with azithromycin, clofazimine and bedaquiline. Mycobacterium infections following ACL reconstruction are exceedingly rare in the United States. Successful management of Mycobacterium abscessus infection is exceptionally challenging for both orthopedists and infection disease specialists.

Article Details

How to Cite
Emerson, C. P., Brecount, H., Quintero, D., Greif, D. N., Jose, J. ., & Kaplan, L. . (2021). Mycobacterium abscessus subsp. massiliense infection secondary to traumatic anterior cruciate ligament reconstruction surgery. Brazilian Journal of Case Reports, 1(4), 22–30. https://doi.org/10.52600/2763-583X.bjcr.2021.1.4.22-30
Section
Clinical Case Reports
Author Biographies

Christopher P. Emerson, University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine

University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL, USA.  

Hogan Brecount, University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine

University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL, USA.  

Daniel Quintero, University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine

University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL, USA.  

Dylan N. Greif, University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine

University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL, USA.  

Jean Jose, Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Hospital

Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, USA.  

Lee Kaplan, University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine

University of Miami Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL, USA.  

References

Gobbi A, Karnatzikos G, Chaurasia S, Abhishek M, Bulgherhoni E, Lane J. Postoperative Infection After Anterior Cruciate Ligament Reconstruction. Sports Health. 2016 Mar-Apr;8(2):187-9. doi: 10.1177/1941738115618638.

Pérez-Prieto D, Trampuz A, Torres-Claramunt R, Eugenia Portillo M, Puig-Verdié L, Monllau JC. Infections after Anterior Cruciate Ligament Reconstruction: Which Antibiotic after Arthroscopic Debridement? J Knee Surg. 2017 May;30(4):309-313. doi: 10.1055/s-0036-1584559.

Murphy MV, Du DT, Hua W, Cortez KJ, Butler MG, Davis RL, DeCoster TA, Johnson L, Li L, Nakasato C, Nordin JD, Ramesh M, Schum M, Von Worley A, Zinderman C, Platt R, Klompas M. Risk Factors for Surgical Site Infections Following Anterior Cruciate Ligament Reconstruction. Infect Control Hosp Epidemiol. 2016 Jul;37(7):827-33. doi: 10.1017/ice.2016.65.

Palazzolo A, Rosso F, Bonasia DE, Saccia F, Rossi R; Knee Committee SIGASCOT. Uncommon Complications after Anterior Cruciate Ligament Reconstruction. Joints. 2018 Nov 30;6(3):188-203. doi: 10.1055/s-0038-1675799.

Nag HL, Neogi DS, Nataraj AR, Kumar VA, Yadav CS, Singh U. Tubercular infection after arthroscopic anterior cruciate ligament reconstruction. Arthroscopy. 2009 Feb;25(2):131-6. doi: 10.1016/j.arthro.2008.09.009.

Oh HL, Chen DB, Seeto BG, Macdessi SJ. Mycobacterium fortuitum infection after anterior cruciate ligament reconstruction using a polylactic acid bioabsorbable screw: Case report. Knee. 2010 Mar;17(2):176-8. doi: 10.1016/j.knee.2009.08.004.

Spanyer JM, Foster S, Thum-DiCesare JA, Kwon YM, Burke DW, Nelson SB. Mycobacterium abscessus: A Rare Cause of Periprosthetic Knee Joint Infection. Am J Orthop (Belle Mead NJ). 2018 Sep;47(9). doi: 10.12788/ajo.2018.0077.

Goldstein N, St Clair JB, Kasperbauer SH, Daley CL, Lindeque B. Nontuberculous Mycobacterial Musculoskeletal Infection Cases from a Tertiary Referral Center, Colorado, USA. Emerg Infect Dis. 2019 Jun;25(6):1075-1083. doi: 10.3201/eid2406.181041.

Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ Jr, Winthrop K; ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416. doi: 10.1164/rccm.200604-571ST.

Mougari F, Guglielmetti L, Raskine L, Sermet-Gaudelus I, Veziris N, Cambau E. Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. Expert Rev Anti Infect Ther. 2016 Dec;14(12):1139-1154. doi: 10.1080/14787210.2016.1238304.

Brown-Elliott BA, Molina S, Fly T, Njie O, Stribley P, Stephenson D, Wallace RJ Jr, Perry JD. Evaluation of a novel rapidly-growing mycobacteria medium for isolation of Mycobacterium abscessus complex from respiratory specimens from patients with bronchiectasis. Heliyon. 2019 Oct 24;5(10):e02684. doi: 10.1016/j.heliyon.2019.e02684.

Hurst-Hess K, Rudra P, Ghosh P. Mycobacterium abscessus WhiB7 Regulates a Species-Specific Repertoire of Genes To Confer Extreme Antibiotic Resistance. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01347-17. doi: 10.1128/AAC.01347-17.

Kim M, Ha CW, Jang JW, Park YB. Rapidly growing non-tuberculous mycobacteria infection of prosthetic knee joints: A report of two cases. Knee. 2017 Aug;24(4):869-875. doi: 10.1016/j.knee.2017.04.015.

Petrosoniak A, Kim P, Desjardins M, Lee BC. Successful treatment of a prosthetic joint infection due to Mycobacterium abscessus. Can J Infect Dis Med Microbiol. 2009 Fall;20(3):e94-6. doi: 10.1155/2009/968052.

Ng SW, Yee Han DL. Lessons learnt from an atypical mycobacterium infection post-anterior cruciate ligament reconstruction. Clin Orthop Surg. 2015 Mar;7(1):135-9. doi: 10.4055/cios.2015.7.1.135.